Ryan Ratts MD, PhD

Ryan Ratts MD, PhD

Dr. Ratts serves on the NEPDC Technical Advisory Board as the clinical representative from Children’s Hospital at Dartmouth (CHaD). Ryan completed his MD/PhD at Boston University and his residency training in the Harvard Combined Medicine-Pediatrics Residency Program with Internal Medicine training at Massachusetts General Hospital and Pediatrics training at Children’s Hospital Boston. He is currently working as both an Adult and Pediatric Hospitalist at Dartmouth Hitchcock Medical Center. In addition to attending on the wards, Ryan also splits his time doing basic science research on the mechanism of entry of diphtheria toxin into host cells. This research is an extension of his PhD work performed in John Murphy’s, PhD, laboratory, and focuses on how the toxin exploits basic protein sorting and vesicle trafficking pathways to gain access into targeted cells. This research allows for rational re-engineering of the toxin translocation machinery as a nano-device for the delivery of biological macromolecules inside specifically targeted cells.